I've mentioned this topic in the comments but enough people are interested that I should sound off in a more official capacity. Recently, given that most people know that Jessica Lange plans to depart after Season 4, Ryan Murphy has started dropping casting wishlists for future seasons of American Horror Story. He name-checked both Reese Witherspoon (errr...okay?) and Michelle Pfeiffer (duh!). Pfeiffer is, of course, the most logical choice with which to fill the imposing vacuum that will be Lange's absence as the anthology's resident grande dame guignol. Like Lange, she's a huge respected talent from the 80s (formative years for Murphy) who can really tear it up onscreen but who today's younger TV-watching legions might still feel a certain "discovery" mania about since she hasn't been properly utilized in years.
There's only three problems.